BASE Lean is a novel weight management formula that includes three branded and clinically studied ingredients-- Meratrim plant extract, Capsimax capsicum extract, and Zychrome® chromium complex. This special combination of ingredients may improve lipolysis, thermogenic activity, and insulin function. The ingredients in BASE Lean also help to increase adiponectin levels which facilitate proper fat metabolism and glucose regulation.
Meratrim is a proprietary plant extract blend for weight management derived from two plants, Sphaeranthus indicus and Garcinia mangostana, traditionally used in Southeast Asian culture. Meratrim has been shown in two independent, randomized, double-blind, placebo-controlled clinical studies to significantly reduce body weight, BMI, and waist circumference within 8 weeks when used in combination with a diet and exercise plan. Meratrim appears to achieve this by modulating the accumulation of fat while simultaneously increasing fat burning. Toxicological studies on Meratrim have demonstrated a wide margin of safety.
In vitro studies demonstrate that Meratrim modulates the expression of biomarkers that control adipogenesis and lipogenesis as follows:
- Reduces the expression of the peroxisome proliferator-activated receptor gamma (PPAR) hormone receptor. PPAR induces adipocyte-specific genes involved in the formation and growth of fat cells.
- Reduces the expression of adipocyte differentiation related protein (ADRP). This is a signaling protein which facilitates the uptake of fatty acids to form lipid droplets and adipocyte differentiation.
- Reduces the expression of cluster of differentiation 36 (CD36)—a trans-membrane receptor that facilitates fatty acid uptake by adipocytes.
- Reduces perilipin expression. Perilipins are adipocyte proteins that are localized at the surface of the lipid droplet and inhibit fat break down by restricting access of lipase to the lipid droplet.